Tamoxifen預防腹膜纖維化之機轉及其在生體療效之研究(2/3)
Date Issued
2003
Date
2003
Author(s)
蔡敦仁
DOI
912314B002339
Abstract
Peritoneal dialysis (PD) is a common
modality of renal replacement therapy for
end-staged renal disease (ESRD) patients. Peritoneal fibrosis (PF) will prevent a good
performance of PD and lead to technique
failure. In the first year of this study, the
effect of tamoxifen (TAM) on human
peritoneal mesothelial cells (HPMCs) and
peritoneal fibroblasts was studied. The
TAM inhibit the production collagen I and III
in HPMCs but not in fibroblasts.
Proliferation of both cells are inhibited by
TAM. In the second year, we extend to in
vivo study in rat PF model induced by bleach.
The results showed that TAM will improve
survival and reduce PF. More experiments
of in vivo studies will be performed in the
next two years.
Subjects
Collagen
Fibroblast
Mesothelial
Cell
Cell
Peritoneal Dialysis
Peritoneal Fibrosis
SDGs
Publisher
臺北市：國立臺灣大學醫學院內科
Type
report
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