Treatment outcome of additional dextran to corticosteroid therapy on sudden deafness: Propensity score-matched cohort analysis
Resource
Otolaryngol. Head Neck Surg., 147(6), 1125-1130
Journal
Otolaryngology - Head and Neck Surgery (United States)
Journal Volume
147
Journal Issue
6
Pages
1125-1130
Date Issued
2012
Author(s)
Wang, Chi-Te
Chou, Hsu-Wen
Fang, Kai-Min
Lai, Mei-Shu
Cheng, Po-Wen
Abstract
OBJECTIVE: This study aimed to investigate whether adding low-molecular-weight dextran to oral steroids in patients with idiopathic sudden sensorineural hearing loss resulted in better hearing outcomes than those in patients receiving oral corticosteroids alone. STUDY DESIGN: Historical cohort study. SETTING: Tertiary teaching hospital. SUBJECTS AND METHODS: The authors reviewed the clinical records of 166 patients with idiopathic sudden sensorineural hearing loss. Therapeutic effectiveness was measured by the gain of pure-tone averages and 4 categories of hearing outcome (complete recovery, marked recovery, mild improvement, or no improvement). To manage potential confounding factors associated with treatment allocation, the authors matched the subjects from each group according to the propensity score (ie, the predicted probability that they would receive a specific treatment). RESULTS: The authors identified 50 pairs of propensity score-matched subjects (n = 100) without significant difference of all clinical factors (P > .05). Subsequent analyses demonstrated that the average hearing gain in subjects receiving additional dextran to oral steroid was 31.7 ± 21.5 dB, which did not differ from 33.0 ± 21.8 dB in subjects receiving steroids alone (P = .76). Difference of hearing outcomes between the 2 groups was also nonsignificant (P = .92). CONCLUSION: Matching propensity scores successfully balanced the heterogeneity between the dextran and steroid groups. Analytical results demonstrated that adding low-molecular-weight dextran to oral corticosteroids was not associated with greater hearing gain or better hearing outcome in idiopathic sudden sensorineural hearing loss.
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journal article
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