B型肝炎病毒基因型和病毒基因體變異與肝細胞癌發生之相關性研究
Date Issued
2004
Date
2004
Author(s)
高嘉宏
DOI
922314B002136
Abstract
Hepatitis B virus (HBV) infection is a major health problem in Taiwan.
Currently, 4 subtypes and 8 genotypes of HBV are identified worldwide, and
most of them have distinct geographic distributions. The impact of HBV
genotypes on the clinical outcome of chronic HBV infection in Taiwan has
been partially clarified. Our recent data showed that subtypes adw and adr or
genotypes B and C are the predominant HBV strains in Taiwan. In addition,
all adr strains are genotype C whereas 81% and 12% of the adw strains are
genotype B and genotype C, respectively. Clinically, genotype C is associated
with more severe liver disease including cirrhosis and hepatocellular
carcinoma (HCC) whereas genotype B is associated the development of HCC
in young non-cirrhotic patients. Serologically, genotype C tends to have a
higher frequency of hepatitis B e antigen (HBeAg) positivity and a higher
serum HBV DNA level than genotype B. Virologically, genotype C bears a
higher frequency of core promoter mutation than genotype B. Although
superinfection of HBV on top of hepatitis B carriers indeed occurs in Taiwan,
it is rarely associated with acute exacerbations. As to the response to antiviral
treatments, genotype C is associated with a lower response rate to interferon
therapy as compared to genotypes B. Although pathogenic and therapeutic
differences do exist among HBV genotypes in Taiwan, the molecular
virological mechanisms contributing these clinical differences, especially
hepatocarcinogenesis, deserve further exploration. In this study, we therefore
investigated the prevalence of specific mutations of HBV genome in a cohort
of genotype B or C-infected hepatitis B carries in different stages of chronic
liver disease and its risk associated with the development of HCC. Our data
showed that both HBV genotype C and basal core promoter mutant were
independent factors for HCC development. Therefore different HBV
genotypes and viral mutants may have different contribution to the
pathogenesis of HBV infection.
Subjects
chronic hepatitis B, hepatitis B virus, hepatocellular carcinoma,
genotype, genomic variation.
genotype, genomic variation.
SDGs
Publisher
臺北市：國立臺灣大學醫學院臨床醫學研究所
Type
journal article
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