Lung mechanics in infants with left-to-right shunt congenital heart disease
Journal
Pediatric Pulmonology
Journal Volume
21
Journal Issue
1
Pages
42-47
Date Issued
1996
Author(s)
Abstract
To clarify which hemodynamic measurement correlates best with lung mechanics in infants with congenital heart disease and left-to-right shunts, dynamic pulmonary function tests and echocardiography were performed in 26 infants with such disease (study infants) and in 37 normal, healthy infants (control infants). The tidal volume and pulmonary compliance (C(L)) were lower and airway resistance higher in infants with congenital heart disease than in control infants. A significant correlation was demonstrated between C(L), expiratory resistance (R(e)), and the right pulmonary artery-to-aortic size ratio (RPA/DAO). C(L) and R(e) also correlated well with the corrected acceleration time √RR ratio (ACT/√RR: ACT, acceleration time and RR: length of the cardiac cycle) of pulmonary flow velocity. Stepwise multiple regression analysis revealed that RPA/DAO correlated best with both C(L) and R(e). It is concluded that infants with congenital heart disease and left-to-right shunts have lower lung compliance and higher expiratory airway resistance than normal children, and that RPA/DAO is the echocardiographic parameter that correlates best with the changes in lung mechanics.
Subjects
acceleration time of pulmonary flow velocity; pulmonary blood flow; pulmonary function; pulmonary hypertension; right pulmonary artery-to-aortic size ratio
SDGs
Other Subjects
article; clinical article; congenital heart disease; controlled study; electrocardiogram; female; heart left right shunt; human; infant; lung function; male; priority journal; Airway Resistance; Blood Pressure; Echocardiography, Doppler, Color; Female; Heart Defects, Congenital; Heart Septal Defects, Ventricular; Hemodynamic Processes; Humans; Infant; Lung Compliance; Male; Pulmonary Artery; Respiratory Function Tests; Respiratory Mechanics
Type
journal article