Correlation between antimicrobial consumption and incidence of health-care-associated infections due to methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci at a university hospital in Taiwan from 2000 to 2010
Journal
Journal of Microbiology, Immunology and Infection
Journal Volume
48
Journal Issue
4
Pages
431-436
Date Issued
2015
Author(s)
Abstract
Objectives: This study was conducted to investigate the correlation between antibiotic consumption and the incidence of health-care-associated infections (HCAIs) caused by methicillin-resistant Staphylococcus aureus (MRSA) (HCAI-MRSA) and vancomycin-resistant enterococci (VREs) (HCAI-VREs) at a university hospital in Taiwan during the period from 2000 to 2010. Methods: Data on annual patient-days and annual consumption (defined daily dose/1000 patient-days) of glycopeptides (vancomycin and teicoplanin), linezolid, fusidic acid, tigecycline, and daptomycin were analyzed. Yearly aggregated data on the number of nonduplicate clinical MRSA and VRE isolates causing HCAI were collected. Results: Overall, the consumption of teicoplanin and linezolid significantly increased during the study period. A significant decrease in the incidence of HCAI-MRSA and a significant increase in the incidence of HCAI-VRE were found during the study period. A significant correlation was found between the increased use of teicoplanin and linezolid and the decreased incidence of HCAI-MRSA. By contrast, positive correlations were found between the consumption of teicoplanin and tigecycline and the incidence of HCAI-VRE. Conclusion: This study identified various correlations between the consumption of antibiotics and the incidence of HCAI-MRSA and HCAI-VRE. Strict implementation of infection-control guidelines and reinforcement of administering appropriate antibiotic agents would be helpful in decreasing the incidence of MRSA and VRE in hospitals. ? 2013 Taiwan Society of Microbiology.
SDGs
Other Subjects
antiinfective agent; daptomycin; fusidic acid; linezolid; teicoplanin; tigecycline; vancomycin; antiinfective agent; antibiotic resistance; Article; bacterium isolate; healthcare associated infection; human; incidence; infection control; methicillin resistant Staphylococcus aureus; nonhuman; practice guideline; Taiwan; university hospital; vancomycin resistant Enterococcus; cross infection; drug utilization; isolation and purification; methicillin resistant Staphylococcus aureus; Staphylococcal Infections; vancomycin resistant Enterococcus; Anti-Bacterial Agents; Cross Infection; Drug Utilization; Hospitals, University; Humans; Incidence; Methicillin-Resistant Staphylococcus aureus; Staphylococcal Infections; Taiwan; Vancomycin-Resistant Enterococci
Publisher
Elsevier Ltd
Type
journal article