Co-regulation of microRNAs and Transcription Factors in Transcriptional Regulation Network
Date Issued
2009
Date
2009
Author(s)
Chen, Cho-Yi
Abstract
MicroRNAs (miRNAs) are small RNA molecules that regulate gene expression at the post-transcriptional level. Recent studies have suggested that miRNAs and transcription factors are primary metazoan gene regulators, but the crosstalk between them still remains unclear. ombing all the potential targets of miRNAs and transcription factors from several published databases and miRNA gene locus information, we first built up an integrative human transcriptional regulation network involving both kinds of regulators and investigated the characterization of miRNA regulation in the integrative network.econdly, we proposed a novel model utilizing functional annotation information to identify significant co-regulation between transcriptional and post-transcriptional layers. Based on this model, function-enriched co-regulation pairs were discovered, and the paired regulators were linked by enriched functions. We further constructed functional co-regulation networks between regulators and investigated their characteristics. ext, we searched for the network motifs consisting of those function-enriched co-regulation pairs and found that an abundance of pairs were closely linked in upstream. Finally, the expression patterns of function-enriched co-regulation pairs were explored. Different co-regulation types showed distinct expression correlation trends. More importantly, we found that the disruption of co-regulation may be closely related to cancers.o conclude, this work uncovers the co-regulation principles between microRNAs and transcription factors, and proposes that coordinated regulation may significantly regulate many biological processes. These findings together elucidated the combinatorial and cooperative properties of TFs and miRNAs co-regulation.
Subjects
systems biology
bioinformatics
microRNAs
transcription factors
transcriptional regulation network
SDGs
Type
thesis
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