The effect of endotoxin adsorber haemoperfusion on microcirculation in septic pigs
Journal
Intensive Care Medicine Experimental
Journal Volume
3
Journal Issue
S1
Date Issued
2015-01-01
Author(s)
Abstract
Microcirculatory dysfunction plays an important role in sepsis-related multiple organ dysfunction.(1) Several studies has shown polymyxin B hemoperfusion has favorable effects on mean arterial pressure, vasopressor use, and mortality.(2) One rat sepsis study had found that microcirculation was better maintained in the polymyxin B hemoperfusion group.(3) However, the effects of polymyxin B hemoperfusion on the microcirculation of the intestinal mucosa, intestinal muscular-serosal layer, kidney, and liver were unknown. We used a fecal peritonitis-induced septic pig model to investigate the effect of polymyxin B perfusion on the microcirculation.
SDGs
Type
other