Antioxidant, antioedema and analgesic activities of Andrographis paniculata extracts and their active constituent andrographolide
Journal
Phytotherapy Research
Journal Volume
23
Journal Volume
23
Journal Issue
7
Journal Issue
7
Pages
958-964
Start Page
958
End Page
964
ISSN
10991573
Date Issued
2009-07
Author(s)
Abstract
Andrographis paniculata (AP), a popular ingredient of Oriental folk medicine, is commonly used for treating infection, inflammation, fever and diarrhoea. In this study, extracts prepared from cultivated AP and their active constituent andrographolide were evaluated for antioxidant, antioedema and analgesic activities. The results showed that the aqueous AP extract (AP-H 2O) exhibited a greater antioxidant activity than the ethanol AP extract (AP-EtOH) in all model systems tested. At a concentration of 50 μg/mL, the free radical scavenging, xanthine oxidase inhibition and antilipid peroxidation activities for AP-H2O were 66.8%, 57.3% and 65.3%, respectively, and for AP-EtOH were 57.8%, 52.6% and 34.2%, respectively. At a dosage of 100 mg/kg, AP-H2O and andrographolide, but not AP-EtOH, showed antioedema and analgesic activities. In phytochemical analysis, AP-H 2O showed a higher concentration of total flavanoid but a lower phenol content than AP-EtOH. In conclusion, AP-H2O was more potent than AP-EtOH in antioxidant activities. Furthermore, compared with andrographolide, AP-H2O as an extract also appears to possess potent antioedema and analgesic activities.
Subjects
Analgesic
Andrographis paniculata
Andrographolide
Antioedema
Antioxidant
SDGs
Other Subjects
alcohol; alpha tocopherol; analgesic agent; Andrographis paniculata extract; andrographolide; antiinflammatory agent; antioxidant; carrageenan; flavanoid; free radical; indometacin; morphine; phenol; xanthine oxidase; analgesic activity; Andrographis paniculata; animal experiment; animal model; animal tissue; antioxidant activity; aqueous solution; article; controlled study; dose response; enzyme inhibition; IC 50; lipid peroxidation; male; nonhuman; pain; paw edema; phytochemistry; rat; writhing test; Analgesics; Andrographis; Animals; Antioxidants; Diterpenes; Edema; Lipid Peroxidation; Male; Mice; Mice, Inbred ICR; Plant Extracts; Rats; Rats, Wistar; Andrographis paniculata
Type
journal article