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  4. Intramucosal variant of nasal natural killer (NK)/T cell lymphoma has a better survival than does invasive variant: Implication on loss of E26 transformation-specific sequence 1 (ETS-1) and T-box expressed in T cells (T-bet) with invasion
 
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Intramucosal variant of nasal natural killer (NK)/T cell lymphoma has a better survival than does invasive variant: Implication on loss of E26 transformation-specific sequence 1 (ETS-1) and T-box expressed in T cells (T-bet) with invasion

Journal
Histopathology
Journal Volume
60
Journal Issue
2
Pages
287-295
Date Issued
2012
Author(s)
Lin T.-C.
SHEE-UAN CHEN  
YA-FANG CHEN  
YEUN-CHUNG CHANG  
CHUNG-WU LIN  
DOI
10.1111/j.1365-2559.2011.04086.x
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84255204441&doi=10.1111%2fj.1365-2559.2011.04086.x&partnerID=40&md5=a266ab8bf6501169e1f4358714fd374d
https://scholars.lib.ntu.edu.tw/handle/123456789/468865
Abstract
Aims: Nasal natural killer/T cell lymphoma (NNKTCL) arises from the nasal mucosa, and spreads to adjacent tissues via local invasion or to regional lymph nodes and distant sites via metastasis. The aims of this study were to determine the impact of invasion on the prognosis of NNKTCL, and correlate invasion with the expression of cytotoxic markers of lymphoma cells. Methods and results: Histopathological evaluations of invasion and immunohistochemistry for cytotoxic markers, including E26 transformation-specific sequence 1 (ETS-1), T-box expressed in T cells (T-bet), signal transducer and activator of transcription (STAT-1), CD56 and granzyme B (GB), were performed in 64 NNKTCLs. There were 17 stage I cases without invasion (stage Ia or intramucosal), 21 stage I cases with invasion (stage Ib), 16 stage II cases and 10 stages III/IV cases. Stage Ia NNKTCLs had a better 5-year overall survival rate than that of stages Ib, II or III/IV NNKTCLs (85%, 38%, 33% and 20%, respectively, P<0.001 by log-rank test). Loss of ETS-1 was found in 24% (four of 17) stage Ia NNKTCLs and in 65% (28 of 43) stages Ib/II/III/IV NNKTCLs (P=0.04, Fisher's exact test); loss of T-bet was found in 29% (five of 17) stage Ia NNKTCLs and in 67% (30 of 45) stages Ib/II/III/IV NNKTCLs (P=0.02, Fisher's exact test). Conclusions: NNKTCL is classically an aggressive lymphoma, but the intramucosal variant is less aggressive. Loss of ETS-1 or T-bet correlated weakly with invasion, a finding that requires further confirmation. ? 2011 Blackwell Publishing Limited.
SDGs

[SDGs]SDG3

Other Subjects
CD56 antigen; granzyme B; STAT1 protein; T box transcription factor; transcription factor Ets 1; adult; article; cancer invasion; cancer staging; cancer survival; female; histopathology; human; immunohistochemistry; major clinical study; male; nasal natural killer t cell lymphoma; natural killer cell; NK T cell lymphoma; overall survival; priority journal; protein expression; T lymphocyte; Adult; Antigens, CD56; Female; Gene Expression Regulation, Neoplastic; Granzymes; Humans; Lymphoma, T-Cell; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Nose Neoplasms; Prognosis; Proto-Oncogene Protein c-ets-1; Sex Characteristics; STAT1 Transcription Factor; Survival Rate; T-Box Domain Proteins; Tumor Markers, Biological
Type
journal article

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