Hirsutalins A-H, eunicellin-based diterpenoids from the soft coral cladiella hirsuta
Journal
Journal of Natural Products
Journal Volume
73
Journal Issue
11
Pages
1785-1791
Date Issued
2010
Author(s)
Abstract
Eight new eunicellin-base diterpenoids, hirsutalins A-H (1-8), were isolated from the soft coral Cladiella hirsuta. Their structures were elucidated by spectroscopic methods, particularly in 1D and 2D NMR experiments. The absolute configuration of 1 was determined by Mosher's method. Compounds 1, 5, and 6 have been shown to exhibit cytotoxicity toward several cancer cell lines. Compounds 2-4 and 8 were found to display significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells by inhibiting the expression of the iNOS protein, with compound 2 also effectively reducing the level of COX-2 protein. ? 2010 The American Chemical Society and American Society of Pharmacognosy.
SDGs
Other Subjects
antiinflammatory agent; cyclooxygenase 2; cytotoxic agent; diterpenoid; hirsutalin a; hirsutalin b; hirsutalin c; hirsutalin d; hirsutalin e; hirsutalin f; hirsutalin g; hirsutalin h; unclassified drug; animal cell; antiinflammatory activity; article; cancer cell culture; carbon nuclear magnetic resonance; Cladiella hirsuta; coral; cytotoxicity; cytotoxicity test; drug isolation; drug structure; drug synthesis; heteronuclear multiple bond correlation; human; human cell; mouse; nonhuman; nuclear Overhauser effect; proton nuclear magnetic resonance; Animals; Anthozoa; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Cyclooxygenase 2 Inhibitors; Diterpenes; Drug Screening Assays, Antitumor; Humans; Lipopolysaccharides; Macrophages; Mice; Molecular Structure; Nitric Oxide Synthase Type II; Nuclear Magnetic Resonance, Biomolecular; Alcyonacea; Cladiella
Type
journal article