MS-20 enhances the gut microbiota-associated antitumor effects of anti-PD1 antibody.
Journal
Gut microbes
ISSN
1949-0984
Date Issued
2024
Author(s)
Lee, Pei-Jung
Hung, Chien-Min
Yang, Ai-Jen
Hou, Cheng-Yu
Chou, Hung-Wen
Chang, Yi-Chung
Chu, Wen-Cheng
Huang, Wen-Yen
Kuo, Wen-Chih
Yang, Chia-Chun
Lin, Kuo-I
Hung, Kuo-Hsuan
Lee, Kang-Yun
Kuo, Han-Pin
Lu, Kung-Ming
Lai, Hsin-Chih
Kuo, Ming-Liang
Chen, Wan-Jiun
Abstract
Cancer immunotherapy has been regarded as a promising strategy for cancer therapy by blocking immune checkpoints and evoking immunity to fight cancer, but its efficacy seems to be heterogeneous among patients. Manipulating the gut microbiota is a potential strategy for enhancing the efficacy of immunotherapy. Here, we report that MS-20, also known as "Symbiota®", a postbiotic that comprises abundant microbial metabolites generated from a soybean-based medium fermented with multiple strains of probiotics and yeast, inhibited colon and lung cancer growth in combination with an anti-programmed cell death 1 (PD1) antibody in xenograft mouse models. Mechanistically, MS-20 remodeled the immunological tumor microenvironment by increasing effector CD8 T cells and downregulating PD1 expression, which were mediated by the gut microbiota. Fecal microbiota transplantation (FMT) from mice receiving MS-20 treatment to recipient mice increased CD8 T-cell infiltration into the tumor microenvironment and significantly improved antitumor activity when combined with anti-PD1 therapy. Notably, the abundance of , which increased following MS-20 treatment, was positively associated with a reduced tumor burden and CD8 T-cell infiltration . Furthermore, an study revealed that MS-20 could alter the composition of the microbiota in cancer patients, resulting in distinct metabolic pathways associated with favorable responses to immunotherapy. Overall, MS-20 could act as a promising adjuvant agent for enhancing the efficacy of immune checkpoint-mediated antitumor therapy.
Subjects
Gut microbiota
cancer immunotherapy
colorectal cancer
SDGs
Type
journal article