Measurements of Arterial Pulse Wave Velocity Using an Ultrasonic Linear Array
Date Issued
2009
Date
2009
Author(s)
Chiu, Po-Kuan
Abstract
Cardiovascular disease is one of the ten most common causes of death in Taiwan and it is mainly caused by arterial stiffness. Pulse wave velocity is commonly used as it is directly related to arterial stiffness. Using the foot-to-foot method, pulse wave velocity can be estimated from pulse wave transit time between two measured locations with a known interval. Traditionally, the global pulse wave velocity between carotid and femoral arteries was estimated using two ultrasonic transducers. With the high frame rate imaging (>= 1000Hz), measurements of local pulse wave velocity with an ultrasonic linear array becomes possible.n this study, an approach based on foot-to-foot method to determine the pulse wave velocity is investigated. With dual transmit beams, the vessel boundaries at two measured sites with a known distance are recorded as a function of time. The pulse wave velocity can therefore be determined by estimating the time delay between the waveforms. To further improve estimation, a Doppler-based method widely used in color flow estimation imaging is adopted. Feasibility of the proposed technique was verified by conducting in vitro flow experiments. For this purpose, the carotid-artery-mimicking phantoms were made and the measured pulse wave velocity was compared to the value predicted by the Moens-Korteweg equation. In vivo measurements were performed on human carotid arteries.ur results of in vitro flow experiment indicate feasibility of dual-beam method. However, further refinement of the experimental setup is necessary. Moreover, reasonable results on pulse wave velocities (4~5 m/s) on two volunteers were obtained by our method in the in vivo experiments.
Subjects
arterial stiffness
pulse wave velocity
foot-to-foot method
high frame rate imaging
ultrasonic linear array
Doppler
Moens-Korteweg equation
SDGs
Type
thesis
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