Effective treatment of 7,12-dimethylbenz(a)anthracene-induced hamster buccal pouch precancerous lesions by topical photosan-mediated photodynamic therapy
Resource
Head Neck-J. Sci. Spec. Head Neck, 34(4), 505-512
Journal
Head and Neck
Journal Volume
34
Journal Issue
4
Pages
505-512
Date Issued
2012
Author(s)
Abstract
Background Previous studies found that topical photodynamic therapy (PDT) is very effective for human oral precancerous lesions. Methods This study evaluated whether topical photosan-mediated PDT (topical photosan-PDT), using a 640-nm light-emitting diode (LED) light, is an effective treatment modality for hamster buccal pouch precancerous lesions. Fourteen 7,12-dimethylbenz(a) anthracene (DMBA)-induced hamster buccal pouch precancerous lesions were treated with topical photosan-PDT using the 640-nm LED light twice a week. Results All 14 of the precancerous lesions showed a complete histologically confirmed response to the lesions after an average of 3.79 (range, 3-5) PDT treatments. Normal and precancerous pouch mucosae in the other 4 hamsters received 17 or 19 treatments of topical photosan-PDT showed no cumulative side effects. No recurrence of the lesions was found in these 18 PDT-treated hamsters after a follow-up period of 50 weeks. Conclusion Our findings indicate that topical photosan-PDT is a very effective treatment modality for DMBA-induced hamster buccal pouch precancerous lesions. Copyright ? 2011 Wiley Periodicals, Inc.
Subjects
DMBA; hamster buccal pouch precancer; oral precancerous lesions; photosan; topical photodynamic therapy
SDGs
Other Subjects
7,12 dimethylbenz[a]anthracene; hematoporphyrin derivative; animal experiment; animal model; animal tissue; article; cheek pouch precancer; controlled study; follow up; histopathology; light emitting diode; male; nonhuman; photodynamic therapy; precancer; priority journal; treatment outcome; treatment response; 9,10-Dimethyl-1,2-benzanthracene; Administration, Topical; Animals; Biopsy, Needle; Cheek; Cricetinae; Disease Models, Animal; Hematoporphyrins; Immunohistochemistry; Male; Mouth Neoplasms; Photochemotherapy; Photosensitizing Agents; Precancerous Conditions; Random Allocation; Reference Values; Spectrometry, Fluorescence; Treatment Outcome
Type
journal article
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