Comparative effectiveness of valproic acid in different serum concentrations for maintenance treatment of bipolar disorder: A retrospective cohort study using target trial emulation framework
Journal
eClinicalMedicine
Journal Volume
54
Date Issued
2022-12
Author(s)
Chen, Yang-Chieh Brian
Liang, Chih-Sung
Wang, Liang-Jen
Hung, Kuo-Chuan
Carvalho, Andre F
Solmi, Marco
Vieta, Eduard
Tseng, Ping-Tao
Lin, Pao-Yen
Hsu, Chih-Wei
Lai, Edward Chia-Cheng
Abstract
There is a lack of consensus on the optimal serum valproic acid (VPA) concentration for maintenance therapy in bipolar disorder (BD). We aimed to investigate the association between serum VPA levels and risk of mood episode recurrence.
Subjects
Bipolar disorder; Effectiveness; Prophylaxis; Serum level; Valproate
SDGs
Publisher
ELSEVIER
Type
journal article