Cortisol awakening response in patients with bipolar disorder during acute episodes and partial remission: A pilot study
Journal
Psychiatry Research
Journal Volume
258
Pages
594-597
Date Issued
2017
Author(s)
Abstract
This exploratory study examined the cortisol awakening response (CAR) in patients with bipolar disorder (BPD) at acute phases and partial remission of manic or depressive episodes. Saliva samples of twenty-seven BPD inpatients and 25 healthy controls were collected to determine the CAR patterns, and 12 patients were sampled again at partial remission. BPD patients exhibited a non-enhanced CAR pattern. Lower cortisol expression and a blunted CAR distinguished bipolar-depressive patients from the controls. The intra-individual follow-up for both patient groups revealed a non-significant improvement in CAR patterns, indicating a trend of a normalized CAR after partial remission for BPD patients. ? 2017 Elsevier B.V.
SDGs
Other Subjects
hydrocortisone; hydrocortisone; adult; aged; arousal; Article; bipolar disorder; clinical article; controlled study; cortisol awakening response; depression; disease association; exploratory research; follow up; human; mania; patient assessment; pilot study; priority journal; remission; saliva analysis; symptom; bipolar disorder; case control study; metabolism; middle aged; pathophysiology; saliva; wakefulness; Adult; Bipolar Disorder; Case-Control Studies; Depression; Humans; Hydrocortisone; Middle Aged; Pilot Projects; Saliva; Wakefulness
Type
journal article