Inside Cover: 1-Arylsulfonyl-5-(N-hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors (ChemBioChem 10/2013)
Journal
ChemBioChem
Journal Volume
14
Journal Issue
10
Pages
1150-1150
Date Issued
2013
Author(s)
Lee H.-Y.
Lai M.-J.
Huang H.-L.
Hsieh Y.-L.
Liu Y.-M.
Yeh T.-K.
Li Y.-H.
Mehndiratta S.
Teng C.-M.
Liou J.-P.
Abstract
The inside cover picture shows a SAR study of synthetic N-hydroxyacrylamides, described by J.-P. Liou et al. on p. 1248 ff., that identified 3-[1- (4-methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-5-yl]-N-hydroxyacrylamide as a potent HDAC inhibitor. This compound not only suppresses the production of lipopolysaccharide-induced cytokines but also markedly reduces carrageenan-induced inflammation in rat. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Type
journal article