Transfer of CMY-2 Cephalosporinase from Escherichia coli to Virulent Klebsiella pneumoniae Causing a Recurrent Liver Abscess
Resource
Antimicrob. Agents Chemother., 59(8), 5000-5002
Journal
Antimicrobial Agents and Chemotherapy
Pages
5000-5002
Date Issued
2015
Date
2015
Author(s)
Abstract
A CMY-2-producing capsular type K2 Klebsiella pneumoniae strain (TVGHKP93) with multidrug resistance was isolated from a recurrent liver abscess in a patient who also carried a CMY-2-producing Escherichia coli strain (TVGHEC01) in the stool. TVGHKP93 retained its high virulence compared with that of the isogenic strain (TVGHKP60) with wild-type resistance from the first liver abscess. Our conjugation experiment showed the successful transfer of the bla(CMY-2)-carrying plasmid from TVGHEC01 into TVGHKP60. The transconjugant showed both high virulence and the multidrug-resistant phenotype, as did TVGHKP93.
SDGs
Other Subjects
amikacin; ampicillin; beta lactamase; cefazolin; cefepime; cefoxitin; ceftazidime; ceftriaxone; cefuroxime; ciprofloxacin; cotrimoxazole; ertapenem; gentamicin; imipenem; levofloxacin; beta-lactamase CMY-2; aged; animal experiment; animal model; antibiotic sensitivity; Article; bacterial gene; bacterial growth; bacterial strain; bacterial virulence; bacterium culture; bacterium identification; bacterium isolation; case report; colony forming unit; controlled study; diabetes mellitus; diabetic patient; DNA fingerprinting; Escherichia coli; feces analysis; gene transfer; growth rate; high throughput sequencing; hospital discharge; human; Klebsiella pneumoniae; lethal dose; lethality; liver abscess; male; minimum inhibitory concentration; mouse; multidrug resistance; multilocus sequence typing; murine model; nonhuman; phenotype; plasmid; priority journal; pulsed field gel electrophoresis; recurrent infection; rmpA gene; rmpA2 gene; septicemia; survival rate; treatment duration; treatment response; very elderly; wild type; enzymology; Escherichia coli; Escherichia coli infection; feces; genetics; Klebsiella infection; Klebsiella pneumoniae; liver abscess; microbiology; virulence; beta-Lactamases; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Infections; Feces; Humans; Klebsiella Infections; Klebsiella pneumoniae; Liver Abscess; Plasmids; Virulence