Prospective comparison of short and long GnRH agonist protocols using recombinant gonadotrophins for IVF/ICSI treatments
Journal
Reproductive BioMedicine Online
Journal Volume
16
Journal Issue
5
Pages
632-639
Date Issued
2008
Author(s)
Abstract
This is a prospective comparative study investigating cost and effectiveness of IVF/ intracytoplasmic sperm injection (ICSI) treatments after stimulation with recombinant gonadotrophins following either the short or long gonadotrophin-releasing hormone (GnRH) agonist protocol. Patients in the short protocol (n = 120) were administered buserelin nasal sprays from day 2 of the menstrual cycle and recombinant FSH from day 5. Patients in the long protocol (n = 120) were administered buserelin from the previous mid-luteal phase and recombinant FSH after achieving down-regulation. The average age and basal FSH concentrations of both groups were similar. The serum LH concentrations during ovarian stimulation were significantly higher with the short protocol. The total cost of recombinant gonadotrophins (US$527 ± 184 versus US$795 ± 244, P < 0.001) was significantly lower in the short protocol, but there was no significant difference in delivery rates (47.5 versus 36.7%) between the short and long protocols. LH flare-up during the short protocol does not seem to impair the treatment outcome. Using recombinant gonadotrophins, the short GnRH agonist protocol is an effective and cheaper choice for IVF/ICSI treatments. ? 2008 Published by Reproductive Healthcare Ltd.
SDGs
Other Subjects
buserelin acetate; chorionic gonadotropin; gonadotropin; luteinizing hormone; recombinant follitropin; recombinant gonadotropin; recombinant luteinizing hormone; adult; article; clinical protocol; clinical trial; controlled clinical trial; controlled study; cost effectiveness analysis; down regulation; drug cost; drug response; female; female infertility; fertilization in vitro; human; intracytoplasmic sperm injection; luteal phase; luteinizing hormone blood level; major clinical study; ovulation induction; pregnancy outcome; randomized controlled trial; single drug dose; treatment duration
Type
journal article