IV delivery of induced pluripotent stem cells attenuates endotoxin-induced acute lung injury in mice
Journal
Chest
Journal Volume
140
Journal Issue
5
Pages
1243-1253
Date Issued
2011
Author(s)
Shih, H.-C.
How, C.-K.
Chen, C.-Y.
Hsu, H.-S.
Yang, C.-W.
Lee, Y.-C.
Perng, R.-P.
Peng, C.-H.
Li, H.-Y.
Chang, C.-M.
Chiou, S.-H.
Abstract
IV delivery of iPS cells provides a beneficial effect to attenuate the severity of endotoxin-induced ALI and improve physiologic impairment, which is partly mediated by a reduction in NF-κB activity and neutrophils accumulation. The conditioned medium of iPS cells demonstrated effects equal to those of iPS cells.
SDGs
Type
journal article