組織工程用、生物可分解鷹架之特性對於軟骨細胞特定分化功能表現之影響研究
Date Issued
2003-11-01
Date
2003-11-01
Author(s)
DOI
912218E002032
Abstract
The choice of scaffold materials has the potential to dramatically affect the outcome of
engineered tissues. Ideally, the scaffold material must support cell adhesion, growth, and
differentiated cell functions. Many properties of scaffolds for tissue engineering might influence
these cell behaviors, such as the types of materials, pore sizes and porosity of scaffolds. Synthetic
biodegradable polymers, with the advantages of biocompatibility, easy processing, and
reproducible, are a group of a group of materials for use as tissue engineering scaffolds. Much
research has focused on chondrocyte interactions with the scaffolds made of those biodegradable
polymers that are FDA approved: polyglycolic acid (PGA), poly(L-lactic acid) (PLLA), and their
copolymer, poly(lactic-co-glycolic acid) (PLGA). Nevertheless, most of the studies focused on
how well chondrocytes attach to and grow in the scaffolds. On the other hand, few studies are
concerning another important aspect, how the scaffolds support chondrocyte-specific functions.
The lack of knowledge regarding the effects of scaffold properties on differentiated cell functions
hampers the development in the field of engineered tissues.
Publisher
臺北市：國立臺灣大學化學工程學系暨研究所
Type
report
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