Topoisomerase I Inhibition Radiosensitizing Hepatocellular Carcinoma by RNF144A-mediated DNA-PKcs Ubiquitination and Natural Killer Cell Cytotoxicity
Journal
Journal of clinical and translational hepatology
Journal Volume
11
Journal Issue
3
Date Issued
2023-06-28
Author(s)
Abstract
Topoisomerase I (TOP1) participates the repair of DNA double-strand breaks (DSBs) upon radiation therapy (RT). RNF144A mediates ubiquitination of catalytic subunit of DNA protein kinase (DNA-PKcs), a critical factor in DSB repair. This study aimed to investigate the natural killer (NK) cell-mediated radiosensitization with TOP1 inhibition and the mechanism by DNA-PKcs/RNF144A.
Subjects
DNA topoisomerase I; Hepatocellular carcinoma; Lipotecan; RNF144A; Radiotherapy
SDGs
Type
journal article