Antinucleosome antibodies correlate with the disease severity in children with systemic lupus erythematosus
Journal
Journal of Autoimmunity
Journal Volume
27
Journal Issue
2
Pages
119-124
Date Issued
2006
Author(s)
Abstract
We compared the serum levels of antinucleosome antibodies (anti-NCS Abs) in thirty pediatric systemic lupus erythematosus (SLE) patients by using enzyme-linked immunosorbent assay (ELISA) to 29 adult SLE patients, 30 healthy controls, 21 juvenile idiopathic arthritis (JIA) and 23 Henoch-Schonlein purpura (HSP) patients as autoimmune disease controls. The mean anti-NCS Ab titer in the pediatric SLE patients was 1552.7 ± 1842.2 U/ml, higher than those of adult SLE patients (194.3 ± 402.7 U/ml), normal controls (9.5 ± 5.7 U/ml) and disease controls (JIA: 7.7 ± 4.0 U/ml, HSP: 5.7 ± 4.4 U/ml) (p < 0.05). The prevalence of both anti-NCS Ab (90%) and anti-ds DNA Ab (76.7%) in pediatric SLE patients were higher (p < 0.05) than that of adult SLE patients (58.6% and 48.3%). A positive correlation was demonstrated between anti-NCS Ab and anti-dsDNA Ab as well as the SLEDAI scores in pediatric and adult patients (p < 0.05). The inverse correlation of anti-NCS Ab levels with C3 was observed in both pediatric and adult SLE patients (pediatrics, r = - 0.61, p = 0.0003; adult, r = - 0.44, p = 0.02). Our data suggested that in pediatric SLE patients, anti-NCS Ab could be as good a marker for SLE diagnosis and disease activity assessment as in adult SLE patients. ? 2006 Elsevier Ltd. All rights reserved.
SDGs
Other Subjects
double stranded DNA; nucleosome antibody; adolescent; adult; anaphylactoid purpura; antibody blood level; antibody titer; article; autoimmune disease; child; controlled study; correlation analysis; data analysis; disease severity; enzyme linked immunosorbent assay; female; human; juvenile rheumatoid arthritis; major clinical study; male; prevalence; priority journal; scoring system; systemic lupus erythematosus; Adolescent; Adult; Antibodies, Antinuclear; Autoantigens; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Female; Humans; Lupus Erythematosus, Systemic; Male; Nucleosomes
Type
journal article