Effects of Ethanol Extract Derived from Fruit-Body of Antrodia cinnamomea on Inflammation-related Biomarkers in Primary Tumor Microenvironment
Date Issued
2014
Date
2014
Author(s)
Hsu, Chia-Cheng
Abstract
Inflammatory responses play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. Inflammation in the tumor microenvironment induces many tumor-promoting effects. The present study is to investigate the effect of oral administration and skin smear of ethanol extract of fruit body of Antrodia cinnamomea (EEAC) on inflammation-related cytokines and growth factors in the primary tumor microenvironment.
The results showed that EEAC treatment dose-dependently reduced LLC cell viability. For LLC tumor model, oral administration 8 mg/kg of body weight of EEAC significantly reduced COX-2 and VEGF production in serum. In addition, IL-1β、TNF-α、IL-6、COX-2、PTGER2 and VEGF mRNA expression were substantially declined within the tumor microenvironment after oral EEAC treatment, and the primary tumor was significantly suppressed. However, oral administration and skin smear of EEAC showed no significant variation neither in tumor growth nor inflammation-related factor expression in serum and the tumor microenvironment between the treated mice.
To sum up, EEAC reduced LLC cell viability, COX-2 and VEGF production in serum, and inflammation-related mRNA expression declined within the tumor microenvironment. Results obtained from the present study may suggest that EEAC may possess a potentiality for cancer chemotherapeutic activity.
Subjects
樟芝
樟芝子實體乙醇萃取物
腫瘤微環境
發炎反應
細胞激素
SDGs
Type
thesis
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