Amyloid related cerebral microbleed and plasma Aβ40 are associated with cognitive decline in Parkinson’s disease
Journal
Scientific Reports
Journal Volume
11
Journal Volume
11
Journal Issue
1
Journal Issue
1
Pages
7115
Start Page
7115
ISSN
2045-2322
Date Issued
2021-12
Author(s)
Abstract
Cerebral microbleeds (MBs) have been found in patients with cognitive decline. We aimed to examine whether MBs are associated with motor or cognitive decline in patients with Parkinson’s disease (PD). We enrolled 135 PD patients and 34 healthy controls. All participants underwent brain MRI and plasma biomarker assays, including tau, Aβ42, Aβ40, and α-synuclein. PD with dementia (PDD) was operationally defined as Mini-Mental State Examination (MMSE) score < 26 and advanced motor stage was defined as Hoehn-Yahr stage ? 3 during “on” status. The association between MBs and disease severity was examined using multivariate logistic regression models. More lobar MBs were observed in PD patients than controls (20.7% vs. 3.3%, p = 0.031). PDD patients had more lobar MBs (33.3% vs. 15.6%, p = 0.034), more white matter hyperintensity (p = 0.021) and reduced hippocampal volume (p = 0.001) than PD with normal cognition. The presence of lobar MB (odds ratio = 2.83 [95% confidence interval 1.04–7.70], p = 0.042) and severe white matter hyperintensity (3.29 [1.21–8.96], p = 0.020) was independently associated with PDD after adjusting for vascular risk factors and other confounders. Furthermore, plasma Aβ40 levels were associated the MMSE score (p = 0.004) after adjusting for age and sex. Our findings demonstrated that lobar MBs, reduced hippocampal volume, and elevated plasma Aβ40 levels are associated with PDD. ? 2021, The Author(s).
SDGs
Other Subjects
amyloid beta protein; amyloid beta protein[1-40]; biological marker; peptide fragment; aged; blood; brain hemorrhage; case control study; cognitive defect; complication; diagnostic imaging; female; human; male; middle aged; nuclear magnetic resonance imaging; Parkinson disease; severity of illness index; Aged; Amyloid beta-Peptides; Biomarkers; Case-Control Studies; Cerebral Hemorrhage; Cognition Disorders; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Parkinson Disease; Peptide Fragments; Severity of Illness Index
Type
journal article