水腦症腦內多巴胺代謝之研究:氧化脢A,B,及類D2接受器之角色
Date Issued
2003-10-31
Date
2003-10-31
Author(s)
郭夢菲
DOI
912314B002301
Abstract
The dopaminergic system in brain alters in experimental hydrocephalus, however,
the response of monoamine oxidase (MAO), the major metabolizing enzyme of
dopamine, to hydrocephalus was not known. We induced hydrocephalus in neonatal
rats by intracisternal injection of kaolin solution and examined the following changes
in the striatum one week after. The tissue levels of dopamine and its metabolites and
the activity of mRNA of MAO all increased in acute hydrocephalus. These changes
could be reversed by release of cerebrospinal fluid, which also improved the release
of dopamine and its metabolites from the presynaptic membrane. These data suggest
that in acute hydrocephalus MAO plays a role in reducing dopamine, which can cause
cytotoxicity to the brain.
Subjects
Rat
Hydrocephalus
Dopamine
Striatum
Microdialysis
monoamine oxidase
Publisher
臺北市：國立臺灣大學醫學院外科
Type
report
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