Subchronic Effects of Concentrated Ambient Particles on Cardiovascular Toxicity in Myocardial Injury Rats
Date Issued
2009
Date
2009
Author(s)
Chen, Po-Jen
Abstract
Epidemiologic studies have shown that ambient particulate matter (PM) is associated with the mortality and hospital admissions of congestive heart failure. However, the mechanism is still unclear. The goal of this study is to investigate the subchronic effects of concentrated ambient particles (CAPs) on cardiovascular toxicity in rats with myocardial injury. Male SD rats received 150 mg/kg isoproterenol by subcutaneous injection to induce myocardial injury. Ultrafine particle concentrator (UFPC) was used for subchronic CAPs exposure (Whole body inhalation exposure, 5hours/day, 4days/week for 13 weeks). Compared to filter air inhalation controls, CAPs exposure group had significantly higher fibrinogen level (190.7 ±15.0 vs 160.5 ±24.2 mg/dL, p < .05); heart rate variability parameters, HF level, was higher in CAPs exposure group than controls (0.77 ± 0.15 vs 0.31 ± 0.05ms2, p < .05). CAPs group also had higher BNP and CRP level but not significant. Our results showed that PM exposure in rats with myocardial injury had no obvious acute or chronic effect in left ventricle, but increased fibrinogen level and altered cardiac autonomic function. Our results suggest cardiovascular risk factors may increase after chronic exposure to ambient particle under present PM concentration.
Subjects
Congestive heart failure
Myocardial injury
Concentrated ambient particles
Ultrafine particle concentrator
Heart rate variability
Type
thesis
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