Neuromuscular electric stimulation enhances endothelial vascular control and hemodynamic function in paretic upper extremities of patients with stroke
Journal
Archives of Physical Medicine and Rehabilitation
Journal Volume
85
Journal Issue
7
Pages
1112-1116
Date Issued
2004
Author(s)
Abstract
Wang J-S, Chen S-Y, Lan C, Wong M-K, Lai J-S. Neuromuscular electric stimulation enhances endothelial vascular control and hemodynamic function in paretic upper extremities of patients with stroke. Arch Phys Med Rehabil 2004;85:1112-6. Objective To investigate the effects of neuromuscular electric stimulation (NMES) on endothelial vascular control and hemodynamic function in patients in rehabilitation after acute stroke. Design Before-after trial. Setting Inpatients in a tertiary hospital. Participants Sixteen stroke patients (11 women, 5 men) with a mean age of 60.6±19.5 years. Interventions All patients received NMES for paretic wrist extensor and flexor muscles 30 minutes daily, 5 days a week, for 4 weeks. The nonparetic upper extremities, which served as controls, did not receive NMES. Main outcome measures Laser Doppler perfusion testing was conducted to measure cutaneous microcirculatory reponses to transdermal iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP), as specific endothelium-dependent and -independent vasodilators, respectively. Arterial and venous hemodynamic function was also measured by impedance plethysmography. Results Before NMES treatment, the venous capacity and compliance of the paretic extremities did not differ significantly from those of the nonparetic extremities. However, hyperemic arterial inflow, ACh-induced cutaneous perfusion, and the ratio of ACh- to SNP-induced cutaneous perfusion were lower in the paretic than in the nonparetic extremities. After NMES treatment, hyperemic arterial inflow and venous outflow increased by 21.5% and 57.2%, respectively, in the paretic extremities (P<.05). ACh-induced cutaneous perfusion and the ratio of ACh- to SNP-induced cutaneous perfusion were also significantly enhanced in the paretic extremities. In contrast, hyperemic arterial inflow decreased by 39.6% in the nonparetic extremities (P<.05), and endothelium-dependent cutaneous vasodilation also decreased significantly. Conclusions NMES therapy may enhance the hyperemic arterial response and endothelium-dependent dilation in skin vasculature in the paretic upper extremities of patients with stroke. ? 2004 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation.
SDGs
Other Subjects
acetylcholine; nitroprusside sodium; vasodilator agent; adult; aged; arm muscle; artery blood flow; article; clinical article; controlled study; electrostimulation; extensor muscle; female; flexor muscle; hemodynamic monitoring; hospital patient; human; impedance plethysmography; iontophoresis; laser Doppler flowmetry; male; microcirculation; paresis; skin blood flow; stroke; vascular endothelium; vasodilatation; vein blood flow; Acetylcholine; Adult; Aged; Cerebral Hemorrhage; Cerebral Infarction; Cerebrovascular Accident; Electric Stimulation Therapy; Endothelium, Vascular; Female; Ferrous Compounds; Hemodynamic Processes; Humans; Iontophoresis; Male; Microcirculation; Middle Aged; Nitroprusside; Paresis; Upper Extremity; Vasodilation; Vasodilator Agents
Type
journal article