Therapeutic outcomes of combined topical autologous serum eye drops with silicone–hydrogel soft contact lenses in the treatment of corneal persistent epithelial defects: A preliminary study
Journal
Contact Lens and Anterior Eye
Journal Volume
39
Journal Issue
6
Pages
425-430
Date Issued
2016
Author(s)
Abstract
Purpose To evaluate the efficacy of the combination of topical 20% autologous serum eye drops (ASEs) and silicone–hydrogel soft contact lenses (SCLs) for the treatment of corneal persistent epithelial defects (PEDs), and to compare the recurrence of epithelial breakdown with or without continuous use of ASEs after silicone–hydrogel SCLs removal. Methods We conducted a prospective interventional study of 21 eyes of 21 patients with PEDs treated with combined ASEs and silicone–hydrogel SCLs from September 2014 to August 2015. SCLs were removed after total re-epithelialization and patients were subsequently randomized divided into two groups: (1) with and (2) without continuous use of ASEs for an additional 2 weeks. PEDs healing rate and epithelial defect recurrence were evaluated. Results PEDs healed in all eyes within 3 weeks. Recurrence was noted in five eyes (50%) in patients without continued use of ASEs for 2 weeks after total re-epithelialization and SCLs removal during a 3-month follow-up (odds ratio: 23.0; P < 0.05). Recurrent epithelial defects were successfully treated with secondary SCLs application combined with autologous serum use. No adverse events were noted during the entire treatment period. Conclusions The combined use of ASEs and silicone–hydrogel SCLs can successfully treat recalcitrant PEDs. Prolonged use of ASEs after total re-epithelialization can decrease recurrence rates. ? 2016 British Contact Lens Association
Subjects
Autologous serum eye drops; Bandage contact lenses; Corneal epithelial defects; Persistent epithelial defects; Silicone–hydrogel contact lens
SDGs
Other Subjects
eye drops; hydrogen; silicon; eye drops; absence of complications; absence of side effects; adult; Article; clinical article; contact lens; controlled study; cornea disease; cornea epithelium; epithelization; female; follow up; healing; human; intervention study; male; priority journal; prospective study; randomized controlled trial; recurrent disease; serum; treatment outcome; aged; blood autotransfusion; chronic disease; Corneal Diseases; devices; hydrophilic contact lens; middle aged; multimodality cancer therapy; pathology; pilot study; procedures; topical drug administration; treatment outcome; Administration, Topical; Adult; Aged; Blood Transfusion, Autologous; Chronic Disease; Combined Modality Therapy; Contact Lenses, Hydrophilic; Corneal Diseases; Epithelium, Corneal; Female; Humans; Male; Middle Aged; Ophthalmic Solutions; Pilot Projects; Treatment Outcome
Type
journal article