Rs5848 Variant of Progranulin Gene Is a Risk of Alzheimers Disease in the Taiwanese Population
Resource
NEURODEGENERATIVE DISEASES v.8 n.4 pp.216-220
Journal
NEURODEGENERATIVE DISEASES
Journal Volume
v.8
Journal Issue
n.4
Pages
216-220
Date Issued
2011
Date
2011
Author(s)
LEE, MING-JEN
CHEN, TA-FU
CHENG, TING-WEN
CHIU, MING-JANG
Abstract
Progranulin is the precursor of granulins, and its downregulation may lead to neurodegeneration. The single- nucleotide polymorphism rs5848 increases the risk of Alzheimers disease AD. We explored the association between alleles of rs5848 and the risk of AD in the Taiwanese population. The frequency of the homozygous TT genotype 16.4 vs. 10.0% increased in AD subjects by an odds ratio OR of 1 .87 p = 0.03 corrected for APOE epsilon 4, age and gender. Interaction between age and homozygous TT genotype accentuated the risk of AD OR 4.44, p < 0.001. The homozygous TT genotype of rs5848 may play a role in the genetic risk of AD development, especially in the elderly.
Subjects
Alzheimers disease
Progranulin
rs5848 gene variant
Dementia
risk factor