Targeting ER protein TXNDC5 in hepatic stellate cell mitigates liver fibrosis by repressing non-canonical TGFβ signalling
Journal
Gut
Journal Volume
71
Journal Issue
9
Pages
1876
Date Issued
2022-09-01
Author(s)
Hung, Chen-Ting
Chen, Yen-Ting
Wu, Yueh-Feng
Abstract
Liver fibrosis (LF) occurs following chronic liver injuries. Currently, there is no effective therapy for LF. Recently, we identified thioredoxin domain containing 5 (TXNDC5), an ER protein disulfide isomerase (PDI), as a critical mediator of cardiac and lung fibrosis. We aimed to determine if TXNDC5 also contributes to LF and its potential as a therapeutic target for LF.
Subjects
apoptosis; fibrogenesis; gene targeting; hepatic stellate cell; liver cirrhosis
SDGs
Publisher
BMJ PUBLISHING GROUP
Type
journal article