An Implantable FPC-based neural probe with pore and micro-wing structure for minimally invasive surgery
Date Issued
2014
Date
2014
Author(s)
Wang, Yu-Hsuan
Abstract
Literature statistics showed that the needs for low back pain treatment have been increasing. Low back pain can be effectively relieved by pharmacological treatment. However, this type of treatment may cause lots of side effects. Thus, researchers have been seeking other ways to relieve low back pain. Lots of implantable stimulation systems have been developed for long-term treatment. Pulse radiofrequency (PRF) stimulation has been widely used for back pain treatment and still being studied.
This thesis presents a bipolar porous probe for implantable nerve stimulation treatment utilizing minimally invasive surgery (MIS). The probe’s design features micro-wings and pores for cell growth that promote long-term fixation in the body. Two recording pairs detect whether cells grow into the pores, and one pair of stimulating pads stimulates the target nerve. The probe is composed of two layers: one SU-8 layer and one flexible printed circuit (FPC) layer. Results show that SU-8 films can increase the average product of the area moment of inertia and Young’s modulus by 21.17% from 5.81 x〖10〗^(-6) N∙m^2 to 7.04 x〖10〗^(-6) N∙m^2, and that micro-wings can increase the force of fixation by 38.58% from 0.114 N to 0.158 N. From the impedance test, the impedance of the recording pairs in different surroundings shows the apparent difference, indicating that two recording pairs are promising for detecting cells growth.
The designed probe is also compared with a prior work, FPC-based electrode with adhesive microtubes, and other geometry of probes. From the result, a geometric coefficient, m, is defined to show that geometry is also one of the key factors for fixation of probes.
Subjects
植入式電刺激系統
探針
微創手術
微翼
孔洞
軟性電路板
SU-8
Type
thesis
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