Preparation of networks of gelatin and genipin as degradable biomaterials
Journal
Materials Chemistry and Physics
Journal Volume
83
Journal Issue
2-3
Pages
204-208
Date Issued
2004
Author(s)
Abstract
The aim of this study is to prepare networks of Bloom number 300 gelatin and genipin as degradable biomaterials. The cross-linking ability of genipin on gelatin was studied and discs were made from the genipin-fixed gelatin. The swelling ratio, the degree of cross-linking, and the rate of degradation of the discs were measured using ninhydrin assay and differential scanning calorimetry (DSC) experiments. The results indicated that genipin is a good cross-linker for the gelatin. Additionally, varying the concentration of genipin can control the rate of degradation and the degree of cross-linking of the genipin-fixed gelatin. Finally, the concentration of genipin should exceed 0.5% of the overall weight of the gelatin-based material if a complete cross-linking reaction between gelatin and genipin molecules is required. © 2003 Elsevier B.V. All rights reserved.
SDGs
Type
journal article