Proinflammatory Cytokine Reactions in Enterovirus 71 Infections of the Central Nervous System
Resource
CLINICAL INFECTIOUS DISEASES v.36 n.3 pp.269-274
Journal
CLINICAL INFECTIOUS DISEASES
Journal Volume
v.36
Journal Issue
n.3
Pages
269-274
Date Issued
2003
Date
2003
Author(s)
CHANG, LUAN-YIN
Abstract
Enterovirus 71 (EV71) infection can lead to devastating clinical outcomes . An appreciation of the scientific relationship between cytokine response and patient mortality may help limit the risks posed by this deadly illness. We present the results of a study that compared the cerebrospinal fluid (CSF) and serum levels of interleukin-6( IL-6) and interleukin-1β (IL-1β) in 24 patients with EV71 infection. Cases in this study involved diverse manifestations or complications, including encephalitis, poliomyelitis-like syndrome, meningitis, and pulmonary edema . CSF levels of IL-6 in study patients were found to be consistently higher during the first 2 days of central nervous system (CNS) involvement than afterward. Compared with patients who did not have pulmonary edema, patients who experienced pulmonary edema had dramatically varied blood values, including IL-6, white blood cell counts, and glucose levels. Our findings suggest that the combination of CNS and systemic inflammatory response may trigger EV71-related cardiopulmonary collapse.
SDGs
Type
journal article