A simple method to improve the antibiotic elution profiles from polymethylmethacrylate bone cement spacers by using rapid absorbable sutures
Journal
BMC musculoskeletal disorders
Journal Volume
23
Journal Issue
1
Date Issued
2022-10-14
Author(s)
Chen, Chien-Lin
Hsieh, Hao-Ying
Abstract
Antibiotic-loaded bone cement beads and spacers have been widely used for orthopaedic infection. Poor antibiotic elution is not capable of eradicating microbial pathogens and could lead to treatment failure. The elution profiles differ among different cement formulations. Although Simplex P cement has the least release amount, it is widely used due to its ready availability. Previous methods aiming to improve the elution profiles were not translated well to clinical practice. We sought to address this by using easily available materials to improve the elution profile of antibiotics from PMMA, which allows clinicians to implement the method intraoperatively.
Subjects
Antibiotics; Cement; Infection; PMMA; Release
SDGs
Publisher
BMC
Type
journal article