Plasma vascular adhesion protein-1 levels correlate positively with frailty severity in older adults
Journal
Medicine
Journal Volume
99
Journal Issue
30
Date Issued
2020-07-24
Author(s)
Chang, Chin-Hao
Wang, Yu-Ting
Chen, Ching-Yu
Hsu, Chih-Cheng
Lee, Chung-Sheng
Abstract
Geriatric frailty is associated with increased mortality and links to increased inflammatory activity. Vascular adhesion protein-1 (VAP-1) is important in inflammatory process. This study investigates the relationship between plasma VAP-1 level and frailty in older adults.The cross-sectional study recruited community dwelling older adults from a hospital-based comprehensive geriatric assessment program. The demographic data, Fried Frailty Index, metabolic and inflammatory parameters were assessed.A total of 151 participants (76 women, 50.3%) were included in the analysis, and the age (mean ± standard deviation) was 77.1 ± 6.1 years. The mean plasma VAP-1 level (ng/mL) was significantly different (P = .029) among different frailty groups (346.3 ± 86.5 in the robust older adults, 371.6 ± 107.9 in the pre-frail older adults, and 416.6 ± 141.1 in the frail older adults). Multivariate ordered logistic regression analysis also demonstrated that plasma VAP-1 levels were positively associated with frailty severity (P = .039). Analysis of the frailty components with plasma VAP-1 levels showed that the elderly who had "exhaustion" (P = .016) or "weakness" (P = .025) tended to have higher plasma VAP-1 levels.The data support that VAP-1 might represent a potential plasma biomarker of frailty.
SDGs
Other Subjects
amine oxidase (copper containing); AOC3 protein, human; biological marker; cell adhesion molecule; aged; blood; classification; cross-sectional study; female; frail elderly; frailty; geriatric assessment; human; male; severity of illness index; very elderly; Aged; Aged, 80 and over; Amine Oxidase (Copper-Containing); Biomarkers; Cell Adhesion Molecules; Cross-Sectional Studies; Female; Frail Elderly; Frailty; Geriatric Assessment; Humans; Male; Severity of Illness Index
Type
journal article