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  4. Effectiveness of fecal immunochemical testing in reducing colorectal cancer mortality from the One Million Taiwanese Screening Program
 
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Effectiveness of fecal immunochemical testing in reducing colorectal cancer mortality from the One Million Taiwanese Screening Program

Journal
Cancer
Journal Volume
121
Journal Issue
18
Pages
3221-3229
Date Issued
2015
Author(s)
HAN-MO CHIU  
Chen S.L.-S.
Yen A.M.-F.
Chiu S.Y.-H.
Fann J.C.-Y.
YI-CHIA LEE  
SHIN-LIANG PAN  
MING-SHIANG WU  
Liao C.-S.
Chen, Tony Hsiu Hsi  
Koong S.-L.
Chiou S.-T.
DOI
10.1002/cncr.29462
URI
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84940961410&doi=10.1002%2fcncr.29462&partnerID=40&md5=611e4d165af6783f6a7182c51d8101dd
https://scholars.lib.ntu.edu.tw/handle/123456789/482872
Abstract
BACKGROUND: The effectiveness of fecal immunochemical testing (FIT) in reducing colorectal cancer (CRC) mortality has not yet been fully assessed in a large, population-based service screening program. METHODS: A prospective cohort study of the follow-up of approximately 5 million Taiwanese from 2004 to 2009 was conducted to compare CRC mortality for an exposed (screened) group and an unexposed (unscreened) group in a population-based CRC screening service targeting community residents of Taiwan who were 50 to 69 years old. Given clinical capacity, this nationwide screening program was first rolled out in 2004. In all, 1,160,895 eligible subjects who were 50 to 69 years old (ie, 21.4% of the 5,417,699 subjects of the underlying population) participated in the biennial nationwide screening program by 2009. RESULTS: The actual effectiveness in reducing CRC mortality attributed to the FIT screening was 62% (relative rate for the screened group vs the unscreened group, 0.38; 95% confidence interval, 0.35-0.42) with a maximum follow-up of 6 years. The 21.4% coverage of the population receiving FIT led to a significant 10% reduction in CRC mortality (relative rate, 0.90; 95% confidence interval, 0.84-0.95) after adjustments for a self-selection bias. CONCLUSIONS: This large, prospective Taiwanese cohort undergoing population-based FIT screening for CRC had the statistical power to demonstrate a significant CRC mortality reduction, although the follow-up time was short. Although such findings are informative for health decision makers, continued follow-up of this large cohort will be required to estimate the long-term impact of FIT screening if the covered population is expanded. ? 2015 American Cancer Society.
SDGs

[SDGs]SDG3

Other Subjects
hemoglobin; adult; aged; Article; barium enema; cancer diagnosis; cancer incidence; cancer mortality; cancer patient; cancer registry; cancer screening; cancer staging; cause of death; clinical effectiveness; cohort analysis; colonoscopy; colorectal adenoma; colorectal cancer; controlled study; feces analysis; female; government; histopathology; human; immunohistochemistry; major clinical study; male; occult blood test; priority journal; prospective study; public health service; sigmoidoscopy; Taiwanese; tumor invasion; very elderly; Colorectal Neoplasms; early diagnosis; epidemiology; immunohistochemistry; mass screening; middle aged; mortality; occult blood; procedures; Taiwan; Aged; Cohort Studies; Colorectal Neoplasms; Early Detection of Cancer; Female; Humans; Immunohistochemistry; Male; Mass Screening; Middle Aged; Occult Blood; Prospective Studies; Taiwan
Publisher
John Wiley and Sons Inc.
Type
journal article

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