Maternal anemia and the false positive rate of maternal serum screening for Down syndrome
Date Issued
2005
Date
2005
Author(s)
Lin, Ching-Yi
DOI
en-US
Abstract
Objectives: The aim of this study is to examine the relation between maternal anemia and the results of second trimester maternal serum screening for Down syndrome.
Subjects and Methods: This descriptive study included singleton pregnant women’s prenatal examination data in Chung-Shan Medical University Hospital Prenatal Care Clinic from September 2001 to December 2004. The second trimester maternal serum free β-human chorionic gonadotropin (hCG) levels and α-fetoprotein levels (MSAFP) multiples of the median (MoM) values in anemia pregnancies group were compared with non-anemia pregnancies group. At the same time, we compared the false-positive rate of maternal serum screening for Down syndrome in anemia pregnancies with non-anemia pregnancies.
Results: Nine hundreds and forty eight of first trimester maternal hemoglobin (Hb) data and second trimester maternal serum screening results were collected from singleton pregnant women. There were 107 of anemia women with the mean hemoglobin concentration 10.26±0.66 g/dL, 841 of non-anemia women with the mean hemoglobin concentration 12.38±0.76 g/dL. There were 43 women with “positive results” (the risk > 1/270) of maternal serum screening for Down syndrome and carried normal karyotypes of the fetus. The false positive rate of maternal serum screening was 4.54% in study subject. The false positive rates were 5.61% and 4.40% in anemia women and non-anemia women, the Odds ratio 1.26 (95%CI 0.53 to 3.13, p>0.05). There was not significant difference between anemia and false positive result of maternal serum screening for Down syndrome.
Conclusion: This present study did not revealed significant elevated false positive rate of second trimester maternal serum screening for Down syndrome in anemia pregnancy detected during first trimester. Anemia does not interfere second trimester maternal serum screening result for Down syndrome.
Subjects
貧血
唐氏症
染色體異常
產前篩檢
甲型胎兒蛋白
人類絨毛膜激素
anemia
Down syndrome
trisomy 21
prenatal screen
AFP
hCG
Type
other
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