Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields
Journal
Applied Physics Letters
Journal Volume
102
Journal Issue
1
Pages
13119
Date Issued
2013
Author(s)
Abstract
In this paper, we report an enhanced liver tumor discrimination for rats using antibody-activated magnetic nanoparticles (MNs) and ultra-low-field magnetic resonance imaging ex vivo. It was found that the intensity ratio between the magnetic resonance image of tumor and normal liver tissues is 2–3 absence of antibody-activated MNs in rats. The intensity ratio rises to ∼100 when antibody-activated MNs are expressed in liver tumors through vein injection. Enhancing tumor discrimination using antibody-activated MNs is demonstrated using T1-weighted contrast imaging in ultra-low magnetic fields.
Type
journal article