Successful treatment of Kasabach-Merritt phenomenon with intralesional corticosteroid injections: A case series
Journal
Annals of Plastic Surgery
Journal Volume
69
Journal Issue
6
Pages
627-632
Date Issued
2012
Author(s)
Abstract
Kasabach-Merritt phenomenon (KMP) is a rare and life-threatening disease of vascular tumor combined with severe consumptive coagulopathy. Currently, there is no established effective treatment of KMP. In this case series, from 2006 to 2008, we treated 6 pediatric patients with newly diagnosed KMP using intralesional corticosteroid injections. The severity and progression of the disease were closely monitored with clinical photographs, blood sampling, and tissue biopsies. The 6 pediatric patients (5 females and 1 male) showed tumor regression after treatments. All coagulopathies were corrected. The average duration of treatment was 3.8 months. Complete tumor regression was observed at approximately 3 years. Treatment was complicated in 1 patient with transient growth retardation. Treatment based on intralesional corticosteroid injections is effective for pediatric patients with KMP. Treatment-associated complications seemed to be reversible and acceptable by severity level. Copyright ? 2012 by Lippincott Williams & Wilkins.
Subjects
corticosteroids; hemangioma; kaposiform hemangioendothelioma; Kasabach-Merritt phenomenon; tufted angioma
SDGs
Other Subjects
corticosteroid; article; female; human; infant; intralesional drug administration; Kasabach Merritt syndrome; male; newborn; remission; Adrenal Cortex Hormones; Female; Humans; Infant; Infant, Newborn; Injections, Intralesional; Kasabach-Merritt Syndrome; Male; Remission Induction
Type
journal article