Chemical and biological assessments of environmental mixtures: A review of current trends, advances, and future perspectives
Journal
Journal of Hazardous Materials
Journal Volume
432
Start Page
128658
ISSN
03043894
Date Issued
2022
Author(s)
Abstract
Considering the chemical complexity and toxicity data gaps of environmental mixtures, most studies evaluate the chemical risk individually. However, humans are usually exposed to a cocktail of chemicals in real life. Mixture health assessment remains to be a research area having significant knowledge gaps. Characterization of chemical composition and bioactivity/toxicity are the two critical aspects of mixture health assessments. This review seeks to introduce the recent progress and tools for the chemical and biological characterization of environmental mixtures. The state-of-the-art techniques include the sampling, extraction, rapid detection methods, and the in vitro, in vivo, and in silico approaches to generate the toxicity data of an environmental mixture. Application of these novel methods, or new approach methodologies (NAMs), has increased the throughput of generating chemical and toxicity data for mixtures and thus refined the mixture health assessment. Combined with computational methods, the chemical and biological information would shed light on identifying the bioactive/toxic components in an environmental mixture. © 2022 Elsevier B.V.
Subjects
Cell-based models
Chemical characterization
Environmental mixture
Mixture modeling
New approach methodology
Toxicity
Publisher
Elsevier B.V.
Description
論文編號: 128658
Type
journal article