Lipid-based gene delivery to macrophage mitochondria for atherosclerosis therapy
Journal
Pharmacology research & perspectives
Journal Volume
8
Journal Issue
2
Pages
e00584
Date Issued
2020-04
Author(s)
Abstract
Atherosclerosis with associated cardiovascular diseases remains one of the main causes of disability and death worldwide, requiring development of new solutions for prevention and treatment. Macrophages are the key effectors of a series of events involved in atherogenesis, such as inflammation, plaque formation, and changes in lipid metabolism. Some of these events were shown to be associated with mitochondrial dysfunction and excessive mitochondrial DNA (mtDNA) damage. Moreover, macrophages represent a promising target for novel therapeutic approaches that are based on the expression of various receptors and nanoparticle uptake. Lipid-based gene delivery to mitochondria is considered to be an interesting strategy for mtDNA damage correction. To date, several nanocarriers and their modifications have been developed that demonstrate high transfection efficiency and low cytotoxicity. This review discusses the possibilities of lipid-based gene delivery to macrophage mitochondria for atherosclerosis therapy.
Subjects
atherosclerosis; gene delivery; liposomes; macrophages; mitochondrial dysfunction; mtDNA damage
SDGs
Publisher
JOHN WILEY & SONS LTD
Type
review