Sertraline alleviated osmophobia caused by partial hypopituitarism with isolated ACTH deficiency
Journal
General Hospital Psychiatry
Journal Volume
35
Journal Issue
5
Pages
574000000000-5740000000000
Date Issued
2013
Author(s)
Abstract
Objective: Hyperosmia may be an early manifestation of hypocortisolism and may be mistakenly diagnosed as osmophobia. However, sertraline therapy incidentally alleviated the phobic symptoms and hindered accurate diagnosis. Case report: A 41-year-old man was diagnosed as having osmophobia. Initial sertraline treatment relieved the symptoms, but its cessation resulted in recurrence of osmophobia. Endocrinological examinations revealed severe hypocortisolism and partial hypopituitarism with isolated adrenocorticotropic hormone deficiency. After prednisolone supplementation, his condition dramatically improved. Conclusion: We recommend that, before intervention with selective serotonin reuptake inhibitors is performed, the hypothalamic-pituitary-adrenal axis be evaluated in psychiatric patients presenting with co-occurring olfactory change. ? 2013 Elsevier Inc.
SDGs
Other Subjects
prednisolone; sertraline; adult; anxiety; article; case report; corticotropin deficiency; disease severity; hospital discharge; human; hydrocortisone blood level; hyponatremia; hypopituitarism; hypothalamus hypophysis adrenal system; male; nausea; osmophobia; partial hypopituitarism; phobia; recurrent disease; symptom; treatment response; Hyperosmia; Hypocortisolism; Hypopituitarism; Osmophobia; Selective serotonin reuptake inhibitor; Adrenocorticotropic Hormone; Adult; Endocrine System Diseases; Genetic Diseases, Inborn; Glucocorticoids; Humans; Hypoglycemia; Hypopituitarism; Male; Odors; Phobic Disorders; Prednisolone; Serotonin Uptake Inhibitors; Sertraline
Publisher
Elsevier Inc.
Type
journal article