Development of recipes for seeded batch crystallization
Date Issued
2011
Date
2011
Author(s)
Tseng, Yu-Ti
Abstract
In this work we investigate the development of recipes for seeded batch crystallization processes. First we investigate the effect of growth rate constraint. For a particular case we find that such a constraint does not have a significant influence on product quality. Then we investigate the effect of seed loading. We find that the seed mass has a large influence on decreasing the final nuclei mass and efficiently suppressed the nucleation rate. In this work seed charts for two dimensional systems and the dimensionless system are produced and used to determine critical seed loading ratio by computer simulation. An analytical expression for the critical seed loading is derived and simulation results show high accuracy for predicting critical seed loading ratio versus dimensionless seed mean size using constant growth rate trajectory. We investigate two critical values which are critical seed surface area and critical seed total length. However these two critical values are not recommended to use as the design variables. In this work we also investigate the effect of total batch time and the net crystal yield on the batch process, and the results can be used as the design guideline.
Subjects
growth rate constraint
critical seed loading ratio
total batch time
the net crystal yield
Type
thesis
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