A POPULATION-BASED STUDY OF THE ASSOCIATION BETWEEN BETEL-QUID CHEWING AND THE METABOLIC SYNDROME IN MEN
Resource
AMERICAN JOURNAL OF CLINICAL NUTRITION v.83 n.5 pp.1153-1160
Journal
AMERICAN JOURNAL OF CLINICAL NUTRITION
Journal Volume
v.83
Journal Issue
n.5
Pages
1153-1160
Date Issued
2006
Date
2006
Author(s)
YEN, AMY, MING-FANG
CHIU, YUEH-HSIA
CHEN, LI-SHENG
WU, HUI-MIN
CHEN, TONY, HSIU-HIS
Abstract
Background: Betel-quid chewing, an established risk factor for oropharyngeal malignancy, is associated with hyperglycemia and obesity. Associations with other characteristics of the metabolic syndrome have not been reported. Objective: This study examined associations between betel-quid chewing and the metabolic syndrome, allowing for recognized risk factors and exploring dose- response effects in a population-based study. Design: Age- specific prevalence rates of the metabolic syndrome were examined in betel-quid chewing and nonchewing men (n = 19 839) recruited into the Keelung Community-based Integrated Screening program in 2001-2003. The independent effect of betel-quid chewing on metabolic syndrome risk was examined by using multiple logistic regression with control for well- recognized risk factors (eg, education, physical activity, and dietary factors) and dose-response effects were examined by using trend tests. Results: The age-adjusted prevalence of the metabolic syndrome was highest in current chewers (25 .13%), next highest in ex-chewers (22.04%), and lowest in nonchewers (15.73%) (P < 0.0001). Odds ratios (95% CIs) for the metabolic syndrome were 1.38 (1.19, 1.60) and 1.78 (1.53 , 2.08) in ex-chewers and current chewers, respectively, adjusted for other significant correlates such as a family history of hypertension and diabetes mellitus. Meaningful odds ratios for the metabolic syndrome components ranged from 1.24 for hyperglycemia (95% CI: 1.09,1.64) to 1.90 (95% CI: 1.66,2.19) for hypertriacylglycerolemia. Increasing odds ratios for the metabolic syndrome with higher consumption of betel quid (whether by rate of use, duration of use, or cumulative exposure) suggest dose-response effects. Conclusions: After adjustment for well-established risk factors, our study showed independent predictive dose- response effects of betel-quid chewing for the metabolic syndrome and its components in a population-based study of men with a 15% prevalence of betel-nut chewing.
Subjects
metabolic syndrome
betel quid
Areca catechu
chewing
dose- response effect
community-based integrated screening
SDGs
Type
journal article