Heart rate variability during hemodialysis and following renal transplantation
Journal
Transplantation proceedings
Journal Volume
42
Journal Issue
5
Date Issued
2010-06
Author(s)
Abstract
Previous studies have shown awareness of uremic dysfunction in end-stage renal disease (ESRD) patients. Dysautonomia in ESRD patients may be reversible after renal transplantation. We used a power spectral analysis (PSA) of heart rate variability (HRV) to assess alterations of autonomic activity in 14 controls and 14 nondiabetic hemodialysis ESRD patients who had undergone renal transplantation. Compared with matched control subjects, the power frequency determinations of low frequency (LF; 3.42 ln(ms(2)) vs 6.38 ln(ms(2)); P < .05 high frequency (HF; 2.29 ln(ms(2)) vs 5.27 ln(ms(2)); P < .05)), and total power (TP; 5.39 ln(ms(2)) vs 7.53 ln(ms(2)); P < .05) were significantly suppressed in ESRD patients undergoing hemodialysis. ESRD patients showed significantly improved HRV after renal transplantation. After renal transplantation, there was no significant difference in the TP (6.82 ln(ms(2)) vs 7.53 ln(ms(2)); P = .15) component between measurements in both patient subgroups. We further divided the ESRD patients into 2 groups based on their pretransplantation HRV, observing alterations in HRV after renal transplantation. Patients with significantly improved HRV were those with more suppressed HRV before transplantation (HF <3 In(ms(2)). Autonomic dysfunction in ESRD patients was not irreversible even if severe, and recovery was observed as early as 6 months after transplantation.
SDGs
Other Subjects
creatinine; cyclosporin; hemoglobin; immunosuppressive agent; mycophenolic acid 2 morpholinoethyl ester; tacrolimus; urea; adult; article; autonomic nervous system; clinical article; continuous ambulatory peritoneal dialysis; controlled study; creatinine blood level; dysautonomia; electrocardiogram; female; heart rate; heart rate variability; hemodialysis; hemoglobin determination; human; immunosuppressive treatment; kidney function; kidney graft rejection; kidney transplantation; male; priority journal; treatment outcome; urea blood level; uremia; Electrocardiography; Female; Heart Rate; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Reference Values; Renal Dialysis; Time Factors; Treatment Outcome
Type
journal article