Homogenous, far-reaching tuning and highly emissive QD-silica core-shell nanocomposite synthesized via a delay photoactive procedure; their applications in two-photon imaging of human mesenchymal stem cells
Resource
JOURNAL OF MATERIALS CHEMISTRY,19(44),8314-8319.
Journal
Journal of Materials Chemistry
Journal Volume
19
Journal Issue
44
Pages
8314-8319
Date Issued
2009-12
Date
2009-12
Author(s)
Lai, Chih-Wei
Wang, Yu-Hsiu
Chen, Yu-Chun
Hsieh, Cheng-Chih
Uttam, Borade Prajakta
Hsiao, Jong-Kai
Abstract
In this article, we present the exploration of a facile synthetic tactic incorporating delay-photo-oxidation to recover the loss in emission frequently encountered after encapsulating quantum dots (QDs) inside a silica shell. This facile synthesis procedure reproducibly increases emissive intensity of QDs (core)–SiO2 (shell) (60 nm) nanomaterials by >5 fold (QY from 3% to >15%). The resulting QDs (core)–SiO2 proved to be a single quantum dot in single SiO2, homogeneous and highly monodispered; their emissions have been successfully fine-tuned from visible to the near infrared region. We then demonstrate their power in biological imaging by labeling human mesenchymal stem cells under two-photon confocal microscopy. The results of low cytotoxicity, efficient labeling, and specific location nearby the nucleus characters of these nanoparticles should spark an intensive relevant research within a living system.
Type
journal article
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