New Nardosinanes and 19-Oxygenated Ergosterols from the Soft Coral Nephthea armata Collected in Taiwan
Resource
Journal of Natural Products 67 (9): 1455-1458
Journal
Journal of Natural Products
Journal Volume
67
Journal Issue
9
Pages
1455-1458
Date Issued
2004
Date
2004
Author(s)
Abstract
Five new nardosinane sesquiterpenoids, armatins A-E (1-5), lemnal-1(10)-ene-2,12-dione (6) (a new natural product), and two new cytotoxic 19-oxygenated ergosterols, armatinols A and B (7 and 8), were isolated from the methylene chloride extract of the soft coral Nephthea armata, collected in Taiwan. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity was determined against selected cancer cells.
SDGs
Other Subjects
armatin a; armatin b; armatin c; armatin d; armatin e; armatinol a; armatinol b; ergosterol; lemnal 1(10) ene 2,12 dione; nardosinane derivative; sesquiterpenoid; unclassified drug; antineoplastic activity; article; carbon nuclear magnetic resonance; cell strain HT29; coelenterate; drug isolation; drug structure; human; human cell; Nephthea armata; nuclear Overhauser effect; proton nuclear magnetic resonance; Taiwan; Animals; Anthozoa; Antineoplastic Agents; Drug Screening Assays, Antitumor; Ergosterol; Humans; Leukemia P388; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Sesquiterpenes; Stereoisomerism; Taiwan; Tumor Cells, Cultured; Alcyonacea; Anthozoa; Coelenterata
Type
journal article
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