Distribution of ESBLs, AmpC β-lactamases and carbapenemases among Enterobacteriaceae isolates causing intra-abdominal and urinary tract infections in the Asia-Pacific region during 2008-14: Results from the Study for Monitoring Antimicrobial Resistance Trends (SMART)
Journal
Journal of Antimicrobial Chemotherapy
Journal Volume
72
Journal Issue
1
Pages
166-171
Date Issued
2017
Author(s)
Jean S.-S.
Korman T.
Ellem J.
George N.
Coombs G.
Ling T.
Tsang O.
Balaji V.
Mikamo H.
Kusachi S.
Mizutani T.
Kim M.-J.
Bae I.-G.
Umur N.B.
Rajasekaram D.G.
Taylor S.
Roberts S.
van der Werff K.
Drinkovic D.
Lagamayo E.
Mendoza M.
Tan T.Y.
Krishnan P.
Wang E.
Lu P.-L.
Liu C.-E.
Chuang K.Y.-C.
Yu K.-W.
Chen Y.-S.
Lu M.-C.
Panthuwong S.
Kiratisin P.
Phoung N.T.M.
Phuong D.M.
Van N.T.
Nga T.T.T.
SMART Asia-Pacific Group
Abstract
OBJECTIVES: To investigate the antimicrobial resistance and assess the molecular characteristics of β-lactamases (ESBLs, AmpC β-lactamases and carbapenemases) among Enterobacteriaceae isolates that caused intra-abdominal infections (IAIs) in patients hospitalized in the Asia-Pacific region during 2008-14. METHODS: Multiplex PCR was used to detect the specific types of β-lactamase in 2893 isolates with MICs of ertapenem >0.5 mg/L. In-hospital acquisition times for most isolates were also delineated. RESULTS: -harbouring IAI Enterobacteriaceae isolates were detected exclusively in Vietnam. CONCLUSIONS: The high resistance burden in Vietnam and the Philippines warrants aggressive control policies to combat the worsening trend in antimicrobial resistance among Enterobacteriaceae species causing IAIs.
Type
journal article