Curcumin-loaded polymeric nanoparticles for enhanced anti-colorectal cancer applications
Journal
Journal of Biomaterials Applications
Journal Volume
30
Journal Issue
5
Pages
537-546
Date Issued
2015
Author(s)
Udompornmongkol P.
Abstract
The purpose of the present study was to fabricate polymeric nanoparticles as drug carriers for encapsulated curcumin with enhanced anti-colorectal cancer applications. Nanoparticles were formulated from chitosan and gum arabic, natural polysaccharides, via an emulsification solvent diffusion method. The formation of curcumin nanoparticles was confirmed by Fourier transform infrared spectroscopy and differential scanning calorimeter. The results show that curcumin was entrapped in carriers with +48 mV, 136 nm size, and high encapsulation efficiency (95%). Based on an in vitro release study, we inferred that curcumin nanoparticles could tolerate hydrolysis due to gastric juice or small intestinal enzymes, and therefore, it should reach the colon largely intact. In addition, curcumin nanoparticles had higher anti-colorectal cancer properties than free curcumin due to greater cellular uptake. Therefore, we concluded that curcumin was successfully encapsulated in chitosan-gum arabic nanoparticles with superior anti-colorectal cancer activity. ? SAGE Publications.
Subjects
anti-colorectal cancer
biomaterials
chitosan
Curcumin
drug encapsulation
gum arabic
nanoparticles
SDGs
Other Subjects
Adhesives; Biomaterials; Chitin; Chitosan; Differential scanning calorimetry; Emulsification; Encapsulation; Fourier transform infrared spectroscopy; Nanoparticles; Polymers; Colorectal cancer; Curcumin; Differential scanning calorimeters; Drug encapsulation; Encapsulation efficiency; Gum arabic; Polymeric nanoparticles; Solvent diffusion methods; Diseases; chitosan gum arabic nanoparticle; curcumin; DNA; intestine enzyme; nanoparticle; polysaccharide; unclassified drug; antineoplastic agent; chitosan; curcumin; drug carrier; gum arabic; nanoparticle; antineoplastic activity; apoptosis; Article; colorectal cancer; concentration response; controlled study; differential scanning calorimetry; diffusion; DNA content; drug dosage form comparison; drug formulation; drug hydrolysis; drug release; emulsion; flow cytometry; HCT116 cell line; HT 29 cell line; human; human cell; in vitro study; infrared spectroscopy; intracellular transport; nanoencapsulation; nanofabrication; particle size; priority journal; stomach juice; cell survival; chemistry; colon; Colorectal Neoplasms; drug effects; hydrolysis; pathology; rectum; tumor cell line; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chitosan; Colon; Colorectal Neoplasms; Curcumin; Drug Carriers; Gum Arabic; Humans; Hydrolysis; Nanoparticles; Rectum
Type
journal article