The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm.
Journal
Cell communication and signaling : CCS
Journal Volume
22
Journal Issue
1
Start Page
353
ISSN
1478-811X
Date Issued
2024-07-05
Author(s)
Vo, Thi Thuy Tien
Peng, Tzu-Yu
Nguyen, Thi Hong
Bui, Trang Ngoc Huyen
Wang, Ching-Shuen
Lee, Wei-Ju
Wu, Yang-Che
Lee, I-Ta
Abstract
Copper is a crucial trace element that plays a role in various pathophysiological processes in the human body. Copper also acts as a transition metal involved in redox reactions, contributing to the generation of reactive oxygen species (ROS). Under prolonged and increased ROS levels, oxidative stress occurs, which has been implicated in different types of regulated cell death. The recent discovery of cuproptosis, a copper-dependent regulated cell death pathway that is distinct from other known regulated cell death forms, has raised interest to researchers in the field of cancer therapy. Herein, the present work aims to outline the current understanding of cuproptosis, with an emphasis on its anticancer activities through the interplay with copper-induced oxidative stress, thereby providing new ideas for therapeutic approaches targeting modes of cell death in the future.
Subjects
Copper
Cuproptosis
Oxidative stress
Reactive oxygen species
SDGs
Type
review article